Get the best of News18 delivered to your inbox – subscribe to News18 Daybreak. Follow News18.com on Twitter, Instagram, Facebook, Telegram, TikTok and on YouTube, and stay in the know with what’s happening in the world around you – in real time. London: Jose Mourinho delivered Tottenham’s first away win in the Premier League since January in his first game in charge with a 3-2 win at West Ham to catapult Spurs up to sixth.Son Heung-min, Lucas Moura and Harry Kane got the goals as Mourinho made an instant impact after replacing the sacked Mauricio Pochettino on Wednesday. A much-needed three points will help to endear Mourinho to a skeptical Spurs support who were sad to see Pochettino’s five-and-a-half year spell in charge of the club end just six months after leading the club to a first ever Champions League final.There was no love lost between Mourinho’s Chelsea sides and Tottenham in the past, but his arrival had the desired impact for Spurs chairman Daniel Levy, even if a West Ham team devoid of confidence made for perfect opponents.Mourinho followed Pochettino’s example in leaving out Christan Eriksen with the Dane one of a number of Spurs players into the final months of his contract and showing no signs of agreeing a new deal.”We have to make the right decision for the club,” Mourinho said on Eriksen’s future before kick-off, but his decision to field a front four of Dele Alli with Son, Moura and Kane worked.Kane had smashed the ball past beleaguered West Ham goalkeeper Roberto after just three minutes from Alli’s pass but was denied by the offside flag.An injury to first-choice stopper Lukasz Fabianski has coincided with a run of eight games without a win for West Ham with a string of errors from Roberto spreading a lack of confidence throughout the team.The Spaniard could have done better when Tottenham did open the scoring nine minutes before half-time when another through ball from Alli found Son, whose shot had too much power for the hapless ‘keeper.However, Roberto was blameless for Spurs’ second seven minutes later when a lovely flick from Alli sent Son racing down the left and his inch-perfect cross was met by Moura at the back post.The same two players should have combined for the visitors’ third just two minutes into the second half when Son sent Moura clean through on goal, but the Brazilian dragged his shot wide to the despair of Mourinho, who sank to his knees on the touchline.Tottenham’s celebrations were only put on hold for another two minutes as Serge Aurier’s cross picked out Kane to head home and become the third highest goalscorer in Spurs’ history with 175.The England captain was furious at himself for not adding another on the hour mark as he dallied with just Roberto to beat and was dispossessed by a last-ditch challenge from Issa Diop.Michail Antonio pulled a goal back for the hosts 17 minutes from time, but by the time Angelo Ogbonna scored West Ham’s second six minutes into stoppage time it was too little, too late.West Ham manager Manuel Pellegrini now waits to see if he faces a similar fate to Pochettino.The Hammers were expected to challenge for European qualification in the Chilean’s second season but instead are 16th and in danger of falling even closer towards the relegation zone by the end of the weekend. harry kaneJoe MourinholondonLondon derby First Published: November 23, 2019, 8:24 PM IST
Nashville, Tenn., finally has a luxury hotel as unique as the music that is created in this southern city. The 248-room Hutton Hotel opened in February, and is already attracting a starry clientele that includes country pop star Billy Currington and Tommy Lee.The hotel, which is already a memeber The Leading Hotels of the World, includes 54 suites, the best of which are the two top floor Penthouses, which feature restricted access, private balconies, fireplaces, steam showers, web bars, and technology like 50-inch LCD-HDTVs. The property is also decorated in a green way that doesn’t skimp on luxury. Environmentally friendly amenities include bamboo flooring and furnishings, card readers that disable guest room lighting upon departure, bronze exterior glass for high thermal insulation, a hybrid courtesy vehicle, and much more.To mark its grand opening, the Hutton is offering a “With Love from Nashville” package, which includes a two-night weekend stay for two in a suite, breakfasts en suite, a chilled bottle of champagne, dinner for two at the hotel’s 1808 Grille, and an Amazon.com gift card. The promotion is available through April 30, and costs $479.Call (615) 340-9333 or visit www.huttonhotel.com
Source:https://www.cnio.es/ Aug 9 2018A gene that has for decades been considered a tumor promoter, the PLK1 gene, can also perform the exact opposite function: halting the development of cancer. This finding was made by researchers from the Spanish National Cancer Research Centre (CNIO) and the Germany’s Cancer Research Centre (DKFZ), and is being published in the journal Nature Communications. The role of PLK1 as a target for powerful drugs must now be reviewed since, depending on the type of tumor to be treated, it might be useful to inhibit it, or it might not. For the time being, the scientists have discovered that the expression of PLK1 in breast tumors can determine a different prognosis, depending on the tumor sub-type.The PLK1 gene is essential for the division and proliferation of tumor cells. It has been known for years the overexpression of PLK1 is found in a large variety of tumor types, and on occasions this overexpression is associated with poor prognosis (when a gene is overexpressed in the cell, there is an excess of the protein produced by that gene). For that reason, PLK1 has for decades been considered an oncogene, a gene that promotes the development of tumors. Plk1 is also a therapeutic target, since inhibiting its activity induces the death of cell tumors. In fact, there are Plk1 inhibitors already at advanced clinical stages.However, curiously, the oncogenic nature of PLK1 has never been formally demonstrated. In other words, until now, no experiment has been designed to demonstrate that the overexpression of PLK1 does indeed contribute to tumor development.That was the initial aim of researchers from Spain’s National Cancer Research Centre (CNIO – Madrid) and Germany’s Cancer Research Centre (DKFZ – Heidelberg) at the start of this joint research project. To this end, they modified the genome of a mouse so that it was possible to overexpress the PLK1 gene at will in these animals. The first thing they noted was that these animals did not develop any more tumors than the normal mice. They then crossed their mice with others that expressed the oncogenes H-Ras or Her2 in their breast tissue, and hence they developed very aggressive breast tumors. They expected a much greater incidence of cancer, but the result was unexpected: by overexpressing PLK1 together with the oncogenes, the incidence of tumors was reduced drastically.Related Stories3D breast tumor models may improve drug discovery and testingScientists use advanced imaging to track brain tumor ‘turncoats’Novel anticancer agents show promise to control tumor growth in nearly every cancer type”That was when we realized that something important was happening,” explained Guillermo de Cárcer, one of the lead researchers on this study at CNIO. “And in effect we have shown that not only does PLK1 not act as an oncogene, but surprisingly it acts as a tumor suppressor”.Plk1 as an indicator of breast cancer prognosis. Intrigued, the researchers consulted the breast cancer databases, in search of a link between the expression of PLK1 and patient prognosis. And they confirmed that “the expression of Plk1 can result in a very different type of prognosis depending on the tumor sub-type”, said de Cárcer.In Her2 positive tumors, the expression of PLK1 gives a better prognosis; however, in patients with positive tumors for the expression of the oestrogen receptor (ER+), it’s the complete opposite. Not only does this paper describe the novel action of PLK1 as a tumor suppressor, it also identifies the molecular mechanism of how this suppression occurs. “We have seen that the overexpression of PLK1 increases the number of chromosomes in cells, because after they divide, cells cannot correctly segregate their chromosomes”, said Rocío Sotillo, lead researcher with the Molecular Thoracic Oncology Group at DKFZ.The fact that Plk1 acts as a tumor suppressor could call into question therapeutic strategies based on the inhibition of Plk1. However, Marcos Malumbres, head of the Cell Division and Cancer Research Group at CNIO and coordinator of the paper, trusts that the inhibition of Plk1 is still a valid and useful option.”The fact that Plk1 is a tumor suppressor instead of an oncogene does not mean that Plk1 inhibitors will not be effective against cancer”, said Malumbres. “Many essential components in cell proliferation can be used as targets against cancer in spite of not having any oncogenic activity, owing to the addition of cancer cells to specific cell processes such as cell division”.The work of these researchers bestows value on the PLK1 gene as an oncological biomarker: “Understanding when PLK1 acts as an oncogene or as a tumor suppressor, and in which types of tumors this happens, is clinically extremely relevant when it comes to using this gene as a therapeutic biomarker”, stresses Guillermo de Cárcer.